{"id":3513,"date":"2021-07-07T11:24:47","date_gmt":"2021-07-07T10:24:47","guid":{"rendered":"https:\/\/catapult.org.uk\/?post_type=case_study&p=3513"},"modified":"2021-09-02T15:15:40","modified_gmt":"2021-09-02T14:15:40","slug":"advancing-acute-myeloid-leukaemia-cell-therapy","status":"publish","type":"case_study","link":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/","title":{"rendered":"Advancing acute myeloid leukaemia cell therapy"},"content":{"rendered":"
\n\n
CASE STUDY<\/span>

Advancing acute myeloid leukaemia cell therapy<\/h2> <\/div>

A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.<\/p> <\/div> <\/div>\n \n

\n
\n \n <\/div>\n <\/div> <\/div>\n\n <\/div>\n\n\n
<\/div>\n\n\n\n
\n
\n 2014\n <\/span>\n\n \n\n
\n Therapy TCR Ltd Joint Venture established\n <\/div> <\/div>\n\n
<\/div>\n\n <\/div>
\n 2015\n <\/span>\n\n \n\n
\n Manufacturing contract with Cellular Therapeutics Ltd \n <\/div> <\/div>\n\n
<\/div>\n\n <\/div>
\n 2016\n <\/span>\n\n \n\n
\n Successful interim safety results achieved in trial\n <\/div> <\/div>\n\n
<\/div> \n\n <\/div>
\n 2017\n <\/span>\n\n \n\n
\n Therapy TCR Ltd acquired by UK based Cell Medica\n <\/div> <\/div>\n\n
<\/div>\n\n <\/div>\n\n <\/div> \n\n <\/div><\/div>\n\n\n\n
\n \n \n <\/svg>\n

\n The collaboration between my research team and the Cell and Gene Therapy Catapult has enabled us to begin opening additional clinical trial sites across the UK and Europe for the testing of novel immunotherapies in patients with cancer. <\/p>\n \n

\n Prof Emma C Morris<\/strong>
UCL Institute of Immunity and Transplantation, Chief Investigator and co-inventor as well as Director of the Infection, Immunity and Inflammation Programme at the National Institute for Health Research University College London Hospitals Biomedical Research Centre <\/div>\n \n \n
\n \n \n <\/svg>\n <\/div>\n <\/div>\n\n\n\n

<\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
\n
\n

Ensuring academic breakthroughs reach patients<\/h2>\n\n\n\n
<\/div>\n\n\n\n

One of the approaches to academic engagement in the Cell and Gene Therapy Catapult focusses on commercialisation of research, identifying projects in academia and accelerating them into therapies or enabling technologies, for the benefit of patients.<\/p>\n\n\n\n

A novel cell therapy approach for the treatment of acute myeloid leukaemia developed initially at Imperial College London<\/strong> and then at University College London (UCL)<\/strong> by scientists was advanced further through the formation of a new venture, Catapult Therapy TCR Ltd in 2014, a joint venture with the Cell and Gene Therapy Catapult and the technology transfer companies UCL Business and Imperial Innovations.<\/p>\n\n\n\n

The product is a gene-modified white blood cell (T-cell) receptor therapy targeting a protein (WT1) that is present on the surface of leukaemia cells at very high levels. Modification by gene therapy of a patient\u2019s T cells aims to make their immune system much more effective at recognising and killing leukaemia cells.<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

When Cell and Gene Therapy Catapult initiated the collaboration with Imperial College London and UCL, the manufacturing process to generate these cells was extremely labour intensive. This restricted the rate at which the product could be manufactured and resulted in a high cost of goods, a barrier to the adoption of these novel therapies at the time. Through their joint venture, UCL Business and Imperial Innovations contributed with their relevant patents and know-how to Catapult Therapy TCR Ltd. The Cell and Gene Therapy Catapult provided expertise in many aspects of the project, including clinical trial operations, regulatory affairs, manufacturing, analytical and process development, as well as an investment of \u00a310m to take the therapy into and through Phase II trials. During the first stage of development the industrialisation team at Cell and Gene Therapy Catapult improved the process to reduce the cost of goods by 60% and increase throughput by 39%.<\/p>\n\n\n\n

At the beginning of this collaboration, regulatory and marketing authorisation requirements were not broadly understood for cell and gene therapies. The project showed that existing regulation can be applied successfully to cell and gene therapy products and has paved the way for other clinical trials of cell and gene therapies.<\/p>\n\n\n\n

In 2017, Catapult Therapy TCR Limited was sold to Cell Medica, a cellular immunotherapy company based in the UK. <\/p>\n\n\n\n

<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.<\/p>\n","protected":false},"featured_media":3561,"template":"","meta":{"_external_link_checkbox":false,"_external_link":"","_event_date":"","_featured_case_study":false},"categories":[9],"tags":[34,15],"class_list":["post-3513","case_study","type-case_study","status-publish","has-post-thumbnail","hentry","category-cell-and-gene-therapy","tag-academic-engagement","tag-modernising-health"],"yoast_head":"\nAdvancing acute myeloid leukaemia cell therapy - The Catapult Network<\/title>\n<meta name=\"description\" content=\"A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advancing acute myeloid leukaemia cell therapy - The Catapult Network\" \/>\n<meta property=\"og:description\" content=\"A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/\" \/>\n<meta property=\"og:site_name\" content=\"The Catapult Network\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-02T14:15:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Catapult_UK\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/\",\"url\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/\",\"name\":\"Advancing acute myeloid leukaemia cell therapy - The Catapult Network\",\"isPartOf\":{\"@id\":\"https:\/\/catapult.org.uk\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg\",\"datePublished\":\"2021-07-07T10:24:47+00:00\",\"dateModified\":\"2021-09-02T14:15:40+00:00\",\"description\":\"A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.\",\"breadcrumb\":{\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#primaryimage\",\"url\":\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg\",\"contentUrl\":\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg\",\"width\":1200,\"height\":900},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/catapult.org.uk\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Case Studies\",\"item\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Advancing acute myeloid leukaemia cell therapy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/catapult.org.uk\/#website\",\"url\":\"https:\/\/catapult.org.uk\/\",\"name\":\"The Catapult Network\",\"description\":\"The Innovate UK Catapult Network\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/catapult.org.uk\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Advancing acute myeloid leukaemia cell therapy - The Catapult Network","description":"A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/","og_locale":"en_GB","og_type":"article","og_title":"Advancing acute myeloid leukaemia cell therapy - The Catapult Network","og_description":"A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.","og_url":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/","og_site_name":"The Catapult Network","article_modified_time":"2021-09-02T14:15:40+00:00","og_image":[{"width":1200,"height":900,"url":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@Catapult_UK","twitter_misc":{"Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/","url":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/","name":"Advancing acute myeloid leukaemia cell therapy - The Catapult Network","isPartOf":{"@id":"https:\/\/catapult.org.uk\/#website"},"primaryImageOfPage":{"@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#primaryimage"},"image":{"@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg","datePublished":"2021-07-07T10:24:47+00:00","dateModified":"2021-09-02T14:15:40+00:00","description":"A collaboration between the Cell and Gene Therapy Catapult, University College London and Imperial College London advances a novel cell therapy for the treatment of acute myeloid leukaemia.","breadcrumb":{"@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#primaryimage","url":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg","contentUrl":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2021\/07\/1200px-Chronic_Myeloid_Leukemia_smear_2009-04-09.jpg","width":1200,"height":900},{"@type":"BreadcrumbList","@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/advancing-acute-myeloid-leukaemia-cell-therapy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/catapult.org.uk\/"},{"@type":"ListItem","position":2,"name":"Case Studies","item":"https:\/\/catapult.org.uk\/our-work\/case-studies\/"},{"@type":"ListItem","position":3,"name":"Advancing acute myeloid leukaemia cell therapy"}]},{"@type":"WebSite","@id":"https:\/\/catapult.org.uk\/#website","url":"https:\/\/catapult.org.uk\/","name":"The Catapult Network","description":"The Innovate UK Catapult Network","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/catapult.org.uk\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"}]}},"_links":{"self":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/case_study\/3513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/case_study"}],"about":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/types\/case_study"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/media\/3561"}],"wp:attachment":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/media?parent=3513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/categories?post=3513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/tags?post=3513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}