{"id":876,"date":"2020-12-06T20:21:56","date_gmt":"2020-12-06T20:21:56","guid":{"rendered":"http:\/\/crosscatapultn.wpengine.com\/?post_type=case_study&p=876"},"modified":"2021-07-09T14:33:03","modified_gmt":"2021-07-09T13:33:03","slug":"developing-new-treatments-to-prevent-thrombosis","status":"publish","type":"case_study","link":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/","title":{"rendered":"Developing new treatments to prevent thrombosis"},"content":{"rendered":"
\n\n
CASE STUDY<\/span>

Developing new treatments to
prevent thrombosis<\/h2> <\/div>

LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.<\/p> <\/div> <\/div>\n \n

\n
\n \n <\/div>\n <\/div> <\/div>\n\n <\/div>\n\n
\n \u00a32.7m\n <\/span>\n\n \n\n
\n in potential savings per year\n <\/div>\n\n <\/div>\n\n
<\/div>\n\n <\/div>
\n \u00a35m\n <\/span>\n\n \n\n
\n funding secures from investors\n <\/div> <\/div>\n\n
<\/div>\n\n <\/div>\n\n <\/div> <\/div>\n\n <\/div>\n\n\n
<\/div>\n\n\n\n
\n
\n

Accelerating drug discovery, from bench to bedside<\/h2>\n\n\n\n

<\/p>\n\n\n\n

Anticoagulation therapy is used in a range of conditions such as prevention of stroke in patients with atrial fibrillation or prevention of venous thromboembolism post-surgery as well as other clinical circumstances. New anticoagulant treatments have the potential to save in excess of \u00a32.7 billion per year, by impacting on bleeding and stroke episodes in Europe alone.<\/p>\n\n\n\n

This collaboration addressed the need for effective anti-clotting therapies and minimal bleeding risk. The project aims to develop a first-in-class drug to prevent the formation of a blood clot inside a blood vessel (thrombosis).  The differentiation of this approach should eliminate the risk of increased uncontrolled bleeding, marking a step-change in the management of the condition.<\/p>\n\n\n\n

The 18-month project brings together target biology, disease understanding and chemistry expertise at LUNAC with the University of Leeds, and Medicines Discovery Catapult\u2019s drug discovery know-how and preclinical imaging expertise. <\/p>\n\n\n\n

With the support from Medicines Discovery Catapult in delivering the grant funded project, LUNAC Therapeutics was able to map a route to clinic and start on that journey whilst successfully securing \u00a35M in funding from investors.  <\/p>\n\n\n\n

Currently available anticoagulants have a relatively narrow margin between beneficial effects and undesirable bleeding events, including bleeding in the brain or gut which, in some instances, may be fatal. <\/p>\n\n\n\n

This collaborative R&D work optimises the discovery of a new class of highly specific anticoagulant compounds that block an activated clotting enzyme, Called Factor XII (FXIIa). There is strong evidence that this novel class of compounds will not increase the risk of bleeding. They would, therefore, allow treatment of more at-risk patients, and would also enable safe dose escalation in high-risk patients.  <\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n \n \n <\/svg>\n

\n LUNAC\u2019s research has shown that targeting activated Factor XII has the potential to offer a new treatment option for patients, and we are therefore delighted to have secured Biomedical Catalyst funding to help drive this exciting project forward. <\/p>\n \n

\n Professor Helen Philippou<\/strong>
Scientific Founder of LUNAC Therapeutics <\/div>\n \n \n
\n \n \n <\/svg>\n <\/div>\n <\/div>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n
\n\n
\n\n
\n

MORE CASE STUDIES<\/h2>\n <\/div>
\n \n
Health<\/div>
\n \n <\/div>\n \n <\/div>\n \n
\n \n
\n
CASE STUDY<\/div>\n
Discovery Services platform boosts UK life sciences R&D and international competitiveness<\/div>\n
The Medicines Discovery Catapult Virtual R&D Discovery Services platform helps match UK SMEs to access medicines and drug discovery services and state-of-the-art equipment, enabling deeper market penetration and access to a wider network of customers. <\/div>\n <\/div>\n \n
\n \n <\/div>\n \n <\/div>\n \n <\/div>\n \n <\/a>\n \n <\/div>
\n \n
Skills<\/div>
\n \n <\/div>\n \n <\/div>\n \n
\n \n
\n
CASE STUDY<\/div>\n
How do we address skills needs in transport innovation?<\/div>\n
The Connected Places Catapult is the UK\u2019s innovation accelerator for cities, transport, and place leadership, working alongside key partners to accelerate innovation in the places where we live, work and travel. By assessing, predicting, mapping and delivering much-needed skills for the future, the Catapult is helping to overcome emerging gaps which threaten to impact success in this area of national importance.<\/div>\n <\/div>\n \n
\n \n <\/div>\n \n <\/div>\n \n <\/div>\n \n <\/a>\n \n <\/div> <\/div>\n\n <\/div>\n\n <\/div>","protected":false},"excerpt":{"rendered":"

LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.<\/p>\n","protected":false},"featured_media":833,"template":"","meta":{"_external_link_checkbox":false,"_external_link":"","_event_date":"","_featured_case_study":false},"categories":[10],"tags":[34,15,16],"class_list":["post-876","case_study","type-case_study","status-publish","has-post-thumbnail","hentry","category-medicines-discovery","tag-academic-engagement","tag-modernising-health","tag-accelerating-business-growth"],"yoast_head":"\nDeveloping new treatments to prevent thrombosis - The Catapult Network<\/title>\n<meta name=\"description\" content=\"LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Developing new treatments to prevent thrombosis - The Catapult Network\" \/>\n<meta property=\"og:description\" content=\"LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/\" \/>\n<meta property=\"og:site_name\" content=\"The Catapult Network\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-09T13:33:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"509\" \/>\n\t<meta property=\"og:image:height\" content=\"494\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Catapult_UK\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/\",\"url\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/\",\"name\":\"Developing new treatments to prevent thrombosis - The Catapult Network\",\"isPartOf\":{\"@id\":\"https:\/\/catapult.org.uk\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg\",\"datePublished\":\"2020-12-06T20:21:56+00:00\",\"dateModified\":\"2021-07-09T13:33:03+00:00\",\"description\":\"LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.\",\"breadcrumb\":{\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#primaryimage\",\"url\":\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg\",\"contentUrl\":\"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg\",\"width\":\"509\",\"height\":\"494\",\"caption\":\"test tubes\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/catapult.org.uk\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Case Studies\",\"item\":\"https:\/\/catapult.org.uk\/our-work\/case-studies\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Developing new treatments to prevent thrombosis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/catapult.org.uk\/#website\",\"url\":\"https:\/\/catapult.org.uk\/\",\"name\":\"The Catapult Network\",\"description\":\"The Innovate UK Catapult Network\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/catapult.org.uk\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Developing new treatments to prevent thrombosis - The Catapult Network","description":"LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/","og_locale":"en_GB","og_type":"article","og_title":"Developing new treatments to prevent thrombosis - The Catapult Network","og_description":"LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.","og_url":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/","og_site_name":"The Catapult Network","article_modified_time":"2021-07-09T13:33:03+00:00","og_image":[{"width":509,"height":494,"url":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@Catapult_UK","twitter_misc":{"Estimated reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/","url":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/","name":"Developing new treatments to prevent thrombosis - The Catapult Network","isPartOf":{"@id":"https:\/\/catapult.org.uk\/#website"},"primaryImageOfPage":{"@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#primaryimage"},"image":{"@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#primaryimage"},"thumbnailUrl":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg","datePublished":"2020-12-06T20:21:56+00:00","dateModified":"2021-07-09T13:33:03+00:00","description":"LUNAC Therapeutics, a UK based drug discovery company, together with the Medicines Discovery Catapult and the University of Leeds, are working on the development of an innovative first-in-class anticoagulant treatment drug with minimal bleeding risk.","breadcrumb":{"@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#primaryimage","url":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg","contentUrl":"https:\/\/catapult.org.uk\/wp-content\/uploads\/2020\/12\/MDC-casestudies-Developing-new-drug-treatments-to-prevent-thrombosis-4-Dec-2020-header-e1607534277598.jpg","width":"509","height":"494","caption":"test tubes"},{"@type":"BreadcrumbList","@id":"https:\/\/catapult.org.uk\/our-work\/case-studies\/developing-new-treatments-to-prevent-thrombosis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/catapult.org.uk\/"},{"@type":"ListItem","position":2,"name":"Case Studies","item":"https:\/\/catapult.org.uk\/our-work\/case-studies\/"},{"@type":"ListItem","position":3,"name":"Developing new treatments to prevent thrombosis"}]},{"@type":"WebSite","@id":"https:\/\/catapult.org.uk\/#website","url":"https:\/\/catapult.org.uk\/","name":"The Catapult Network","description":"The Innovate UK Catapult Network","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/catapult.org.uk\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"}]}},"_links":{"self":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/case_study\/876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/case_study"}],"about":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/types\/case_study"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/media\/833"}],"wp:attachment":[{"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/media?parent=876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/categories?post=876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/catapult.org.uk\/wp-json\/wp\/v2\/tags?post=876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}